Genetic abnormality of cytochrome-P2C9*3 allele predisposes to epilepsy and phenytoin-induced adverse drug reactions: genotyping findings of cytochrome-alleles in the North Indian population

نویسندگان

چکیده

Abstract Background This research aims to study the association of genetic polymorphism in genes coding for CYP2C9 and CYP2C19 phenytoin-induced dose-related toxicity assess if presence allele CYP2C9*3 plays a role idiosyncratic adverse effects. Current observational case control included 142 patients with drug reactions (ADRs) 100 controls. All these underwent genotyping determine type [CYP2C9*1, CYP2C9*2 or CYP2C9*3) (CYP2C19*1, CYP2C19*2 CYP2C19*3] by real-time polymerase chain reaction (RT-PCR) using Applied Biosystems (ABI) 7500 Real-Time PCR System (USA). Results Presence homozygous status was associated significantly higher risk dose-dependent ADRs, dose-independent gum hyperplasia, skin rash. heterozygous phyenytoin-induced ADRs ADRs. either did not have any bearing on side None showed CYP2C19*3 allele. Conclusion Variant alleles are overexpressed among thereby suggesting genotype testing predict phenytoin-related

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ژورنال

عنوان ژورنال: Future Journal of Pharmaceutical Sciences

سال: 2022

ISSN: ['2314-7245', '2314-7253']

DOI: https://doi.org/10.1186/s43094-022-00432-6